Backups, Preparedness, and Being On-Point with SER
So SER has backup functions for both projects and settings. I suggest using them both. 
And, don't keep your backups on your VPS or your C: drive (if using a PC).
Make copies onto memory sticks.
Have multiple copies.
Also, keep copies of all your server files, I also suggest using a stick for this.
And of course, a disk image of your SEO Tools system is ultra-wise.
I recently suffered a Windows crash and my most recent disk image was pre-GSA. 
It took extra time(!) also locating the image file, so I suggest keep everything organized and labeled. That, and the fact it was on a drive that has an issue with it's connector, and tiiiiiiiiiiiiiime just flew by. If you keep backups, but do not know where, you're shot.
Do u really want to start searching thru hard drives and sticks for the data you need?!?!?!?! If you're on a SEO vacation, sure, get some piña coladas and enjoy the slow and tedious search process u set up for yourself. 
This may all seem like elementary stuff, but really it's worth considering seriously.
Also, keep notes. Keep your notes within your projects. And, keep your notes in files that are with your backups. Re-installing Windows, I had to do a bunch of tasks I did last time, all over again. If I had notes, finding Registry keys would have been way faster.
A batch file that auto-backs up your Windows GSA folders is an option worth creating. I had this on older iterations of Windows, maybe worthwhile to do again?