I use MS Outlook exclusively and have for the past 5 years or so. It's the default mail program.
In the ES email settings I've added in the to and from addresses, (which are real email addresses) and selected send emails of your default client (MAPI).
I can't change or type into the fields SMTP server, username, or password. This whole section everything is greyed out.
When selecting to auto-mail I get the error, please make sure outlook is your default program, and it doesn't email anyone.