Depends on how much you're trying to post to the same list..
Eg. if you were only ever posting one link per domain (that needed a signup/verify step), you would only actually need one email address...
Most people run the same list through multiple projects, so this means you might need at least a number of email addresses equal to the number of projects you're running..
If you run the same list through again (or post to the same site more than once in tier projects), then you need more..
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